Is frequently used in the treatment of ambulatory patients.  It can reduce nausea and vomiting by action on the CTZ.

Dose:  0.625 – 1.25 mg IV

Onset:  3- 10 minutes

Peak Action:  30 minutes

Duration:  2-4 hours

Potential Adverse Reactions:

  • Mild to moderate hypotension
  • Drowsiness and prolonged recovery when given in larger doses.

Compazine (Prochorperazine)

Dose:  5 – 10 mg IV or deep IM

Administration Technique:  Begin with lowest recommended dose.  No more than 5 mg/minute IV.  Maximum dose of 10 mg IV.

Potential Adverse Reactions: Drowsiness, dizziness

Phenergan (Promethazine)

Dose:  12.5 – 25 mg IV or 25-50 mg IM

Onset:  20 minutes

Peak Action:  4-6 hours

Duration:  Up to 12 hours

Potential Adverse Reactions:  Drowsiness, dry mouth.

Zofran (Ondansetron Hydrochloride)

Dose:  4 mg IV over 2-5 minutes

Onset: 20 minutes

Peak Action:  3.5 hours

Duration:  Up to 8 hours

Potential Adverse Reactions:  Minimal side effects



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