Morphine Sulfate


Binds opiate receptors in CNS, altering perception of and emotional response to pain.



Onset of Action

Peak Effect

Duration of Action


<1 minute

5 – 20 minutes

4-7 hours


5 – 10 minutes

30-60 minutes

4-7 hours


Within 1 hour

1-2 hours

6-12 hours





Give 2 – 10 mg IV. 


  • Must give slowly and titrate to individual response.  


  • Assess patient continuously for signs and symptoms of pain and give additional doses for increasing pain levels. 


  • Decrease dosage if giving to elderly or debilitated patients and in patients with renal or hepatic disease. 


  • Dilute with 5 ml of sterile water or NS and give slowly. 


  • May repeat every 15 minutes. 


  • Total dosage 10 mg in 60 minutes.



0.05 – 0.1 mg/kg  IV, titrated to effect.


Adverse Reactions


  • Respiratory effects – respiratory depression,  bronchospasm, laryngospasm.


  • Cardiovascular effects – hypotension, hypertension, bradycardia, arrhythmias


  • CNS effects – euphoria, dysphoria, somnolence, syncope


  • GI effects – nausea, vomiting, constipation, biliary tract spasm


  • GU – urinary retention


  • Integumentary – pruritis/local tissue irritation, urticaria, skin wheals


  • Musculoskeletal – chest wall rigidity


Reversal Agent 


Naloxone (Narcan) will reverse the respiratory and cardiovascular effects of MS overdose.

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