Morphine Sulfate

 

Binds opiate receptors in CNS, altering perception of and emotional response to pain.

                       

Route

Onset of Action

Peak Effect

Duration of Action

IV

<1 minute

5 – 20 minutes

4-7 hours

IM

5 – 10 minutes

30-60 minutes

4-7 hours

Oral

Within 1 hour

1-2 hours

6-12 hours

 

Dosage/Administration

 

Adults:

Give 2 – 10 mg IV. 

 

  • Must give slowly and titrate to individual response.  

 

  • Assess patient continuously for signs and symptoms of pain and give additional doses for increasing pain levels. 

 

  • Decrease dosage if giving to elderly or debilitated patients and in patients with renal or hepatic disease. 

 

  • Dilute with 5 ml of sterile water or NS and give slowly. 

 

  • May repeat every 15 minutes. 

 

  • Total dosage 10 mg in 60 minutes.

      

Pediatrics:

0.05 – 0.1 mg/kg  IV, titrated to effect.

 

Adverse Reactions

 

  • Respiratory effects – respiratory depression,  bronchospasm, laryngospasm.

 

  • Cardiovascular effects – hypotension, hypertension, bradycardia, arrhythmias

 

  • CNS effects – euphoria, dysphoria, somnolence, syncope

 

  • GI effects – nausea, vomiting, constipation, biliary tract spasm

 

  • GU – urinary retention

 

  • Integumentary – pruritis/local tissue irritation, urticaria, skin wheals

 

  • Musculoskeletal – chest wall rigidity

 

Reversal Agent 

 

Naloxone (Narcan) will reverse the respiratory and cardiovascular effects of MS overdose.

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